Lab for Integrated Protein Design & Structure, KAIST

2026

*Corresponding Author

Ma D, Lee J, Lee H, Lee S-H, Oh YG, Kim Y-e, Jin T, Sutthiwanna S, Lee S-J, Jeon W, Lee DS, Ahn J, Cho R, Park H, Jeong S, Park H*, Bae S-H*, Kim HM*. ProteinSketch translates spatial intuition into protein design with bimanual interaction in VR. Biorxiv, 2026, July 20. ; https://doi.org/10.64898/2026.07.19.739460

#Diffusion-based Protein Design #Virtual Reality #Cryo-EM

Kim S, Lee MH, Ahn J, Ju S-H, Lee DS, Min KW, Shong M*, Kim HM*. Induced-fit anti-GFRAL antibody reverses cancer cachexia and attenuates sympathetic outflow in tumor-bearing mice, Science Advances, Under Revision.

#Antibody development #Cancer-associated cachexia #X-ray Crystallography

Yang YL, Jung S-B, Shin H, Cho B-H, Yun J, Min KW, Lee DS, Kim JC, Kim HM*, Yang J*. Adipocyte LRG1 Promotes Inflammatory Adipose Remodeling Through An LPHN2-IL-6 Axis In Diet-Induced Obesity, Diabetes and Metabolism Journal, Accepted.

#LRG1 #LPHN2-IL-6 axis #Obesity

Cho R, Ahn J, Yang J, Lee DS, Lee S, Kim HM*. Structural basis of lymphangiogenic receptor VEGFR-3 activation mediated by distinctive clustering of the ligand–receptor complex, Advanced Science, Accepted.

#Protein Structure #Cryo-EM

Hong HJ, Lee MH, Park M, Kim JT, Kim J, Ju S-H, Lee JH, Sohn J-W, Song K, Setoyama D, Kim HM, Kim J*, Shong M*. Therapeutic Gfral silencing via antisenseoligonucleotides ameliorates cancer-associatedcachexia and extends survival in tumor-bearing mice. Cell Reports Medicine, 2026, Aug 18. ; https://doi.org/10.1016/j.xcrm.2026.102939

#GFRAL #GDF15 #Cancer-associated cachexia #metabolic dysfunction

Ahn J, Cho R, Kim S, Lee DS, Kim HM*. De novo and scaffold-based design of GDF15 binders for cancer cachexia diagnostics and therapeutics. Experimental & Molecular Medicine, 2026, May 8. ; https://doi.org/10.1038/s12276-026-01727-x

#Protein Design #Drug development #Recombinant protein therapy #Cancer cachexia

Vecchietti LF, Lee M, Hangeldiyev B, Wijaya BN, Jung H, Park H, Kim T-K, Cha M*, Kim HM*. Interpretable Machine Learning for Protein Science: Structure, Function, and Interactions. ACM Computing Surveys, 2026, April 25. ; https://doi.org/10.1145/3801737

#Machine learning #Artificial intelligence #Protein functionality prediction

Kim S, Kim H, Porta Pelayo J, Alvarez S, Jang G, Kim J, Kim B, Hoelscher VM, Calleja-Pérez B, Jung H, Yang Y, Lee HJ, Lee J, Kim S, Jiménez de la Peña M, Lee Y, Kim S, Han A, Lee DS, Ji S, Yu W, Kim HM, An JY, Oh WC, Kwon SK, Kim JY, Um JW, Fernández-Jaén A*, Ko J.* Bazedoxifene reverses sexually dimorphic autistic-like abnormalities in biallelic MDGA1-mutant mice. EMBO Mol Med, 2026, Apr 15. ; https://doi.org/10.1038/s44321-026-00402-y

#MDGA1 #Autism spectrum disorder #Inhibitory synapse #Communication deficits #Social deficits

Yun J, Yang S, Kwon JH, Vecchietti LF, Choi JH, Choi M-R, Ku KB, Ro H-J, Kim K-D, Cha M, Chung HJ*, Oh JE*, Kim HM*. Computational Design and Glycoengineering of Interferon-Lambda for Nasal Prophylaxis against Respiratory Viruses. Advanced Science, 2026 Jan 30. ; https://doi.org/10.1002/advs.202506764

#Protein Design #Drug delivery #Interferon-lambda #Nasal delivery

Lee H, Cho Y, Yun J, Steinegger M, Kim HM*, Park H*. Protein folding stability estimation with explicit consideration of unfolded states. Nature Communications, 2026 Jan 21. ; https://doi.org/10.1038/s41467-026-68637-4

#Protein folding #Energy calculation #AI-Prediction

2025

Bennett NR, Watson JL, Ragotte RJ, Borst AJ, See DL, Weidel C, Biswas R, Yu Y, Shrock EL, Ault R, Leung PJ, Huang B, Goreshnik I, Tam J, Carr KD, Singer B, Criswell C, Wicky B, Vafeados D, Sanchez MG, Kim HM, Torres SV, Chan S, Sun S, Spear T, Sun Y, O’Reily K, Maris JM, Sgourakis NG, Melnyk RA, Liu CC, Baker D*. Atomically accurate de novo design of antibodies with RFdiffusion. Nature, 2025 Nov 5. ; https://doi.org/10.1038/s41586-025-09721-5

#Protein Design #Antibody #de novo protein

Ju X, Zhang T, Cui J, Lee Y, Lee S, Kim HM, Hong B, Park J, Choi CH, Yu H-S, Heo JY, Chung W.* ATF5-Dependent GDF15 Expression in Excitatory Neurons Mediates General Anesthesia-Induced Neuroprotection Against Ischemia/Reperfusion Injury. Advanced Science, 2025 Nov 26. ; https://doi.org/10.1002/advs.202417086

#GDF15 #Excitatory neurons

Yang S, Yun J, Kwon JH, Oh JE*, Kim HM*, Chung HJ*. Intranasal Nanoliposomes Delivering Interferon Lambda with Enhanced Mucosal Retention as an Antiviral. Biomaterials Research. 2025 Nov 21. ; https://doi.org/10.34133/bmr.0287

#Protein Design #Drug delivery #Interferon-lambda #Nasal delivery

Jung H, Kim B, Jang G, Lee H, Kim Y, Kim H, Lee HJ, Kim D, Yang Y, Chung WC, Kim S, Han A-r, Kim HM, Papadopoulos T, Durand B, Francannet C, Piton A, Kim JY*, Ko J*, Um JW*. Autism-associated ARHGEF9 variants impair GABAergic synapses and ultrasonic communication by reducing gephyrin phosphorylation. Molecular Psychiatry, 2025 Oct 31. ; https://doi.org/10.1038/s41380-025-03313-5

#GABAergic synapse #ARHGEF9

Lee H, Lee S, Seo Y, Kim D, Oh Y, Jin J, Hyeon B, Han Y, Kim H, Kim HM, Lee G, Cho K*, and Heo WD*. A Rho GTPase-effector ensemble governs cell migration behavior, Nature Communications, 2025 Oct 31. ; https://doi.org/10.1038/

s41467-025-64635-0

#Rho FTPase #Cell

Vecchietti LF, Wijaya BN, Armanuly A, Hangeldiyev B, Jung H, Lee S, Cha M* and Kim HM*. Artificial intelligence-driven computational methods for antibody design and optimization. mAbs. 2025 Dec; 17(1). ; https://doi.org/10.1080/

19420862.2025.2528902

#Antibody #Antibody design #Antibody strucutre

Fu Y, Kim H, Lee DS, Han A, Heine H, Zamyatina A*, and Kim HM*. Structural insight into TLR4/MD-2 activation by synthetic LPS mimetics with distinct binding modes. Nature Communications. 2025 May 05; 16:4164.

#Protein Structure #Computational Structural Biology #Cryo-EM

Adams CS, Kim H, Burtner AE, Lee DS, Dobbins C, Criswell C, Coventry B, A Tran-Pearson, Kim HM*, and King NP*. De novo design of protein minibinder agonists of TLR3. Nature Communications. 2025 Jan 31;16(1):1234.

#Protein Structure #Computational Structural Biology #Cryo-EM #Vaccine Adjuvant #Drug Development

Oh J, Catherine C, Kim ES, Min KW, Jeong HC, Kim H, Kim M, Ahn SH, Lukianenko N, Jo MG, Bak HS, Lim S, Kim YK, Kim HM*, Lee SB*, and Cho H*. Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin. Nature Communications. 2025 Jan 17;16(1):737.

#Protein Design #Protein Aggregation #Chaperones #Huntington's disease #Collaboration

2022

Kim DK, Jeong J, Lee DS, Hyeon DY, Park GW, Jeon S, Lee KB, Jang J-Y, Hwang D, Kim HM* and Jung K*. PD-L1-directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer-associated fibroblasts in pancreatic cancer. Nature Communications. 2022 Oct 22; 13(1): 6292

#Protein Engineering #Anti-angiogenesis #Drug Development #Human Disease #Cancer #Collaboration

Kim H, Fu Yaoyao, Hong HJ, Lee S-G, Lee DS, Kim HM*. Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex. Nature Communications. 2022 Jul 30;13(1):4434

#Protein Structure #Cryo-EM #Ligand/Receptor complex #Cytokine #Human Disease

Song H-S, Park S, Huh J-W, Lee Y-R, Jung D-J, Yang C, Kim SH, Kim HM, Kim Y-M. N-glycosylation of UNC93B1 at a Specific Asparagine Residue Is Required for TLR9 Signaling. Front Immunol. 2022 Jul 7;13:875083

#Protein Structure #Immune Response #Collaboration

Chehadeh SE, Han KA, Kim D, Jang G, Bakhtiari S, Lim D, Kim HY, Kim J, Kim H, Wynn J, Chung WK, Vitiello G, Cutcutache I, Page M, Gecz J, Harper K, Han A, Kim HM, Wessels M, Bayat A, Fernández-Jaén A, Selicorni A, Maitz S, Arjan de Brouwer, Anneke Vulto-van Silfhout, Armstrong M, Symonds J, Kury S, Isidor B, Cogné B, Nizon M, Feger C, Muller J, Torti E, Grange D, Willems M, Kruer M, Ko J, Piton A, and Um JW. SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice. Nature Communications. 2022 Jul 15;13(1):4112

#Protein Structure #Computational Structure Biology #Neuroscience #Collaboration

Yin GN, Kim D-K, Kang JI, Im Y, Lee DS, Han A-R, Ock J, Choi M-J, Kwon M-H, Limanjaya A, Jung S-B, Yang J, Min KW, Yun J, Koh Y, Park J-E, Hwang D, Suh J-K*, Ryu J-K*, Kim HM*. Latrophilin-2 is a novel receptor for LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function. Experimental & Molecular Medicine. 2022 May;54(5):626-638

#Protein Science #Protein-Protein Interaction #Cell Signaling #Angiogenesis #Nerve Regeneration #Human Disease #Collaboration

Jeon TJ, Lee S-G, Yoo SH, Kim M, Song D, Ryu JH, Park H, Kim DS, Hyun J, Kim HM*, Ryu SE*. A dynamic substrate pool revealed by cryo-EM of a lipid-preserved respiratory supercomplex. Antioxid Redox Signal. 2022 Apr 27. doi: 10.1089/ars.2021.0114. Online ahead of print

#Protein Structure #Cryo-EM #Membrane Protein #Macromolecular Complex #Collaboration

2021

Park M, Han A-R, Kim SY, Kim TY, Kim HM, Lee CJ. High-yield synthesis and purification of recombinant human GABA transaminase for high-throughput screening assays. J Enzym Inhib Med Chem. 2021 Dec;36(1):2016-2024

#Protein Science #Neuroscience #Collaboration

Jo G, Bae J, Hong HJ, Han A-R, Kim D-K, Hong SP, Kim JA, Lee S, Koh GY*, Kim HM*. Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody. Nature Communications. 2021 Nov 1; 12:6287; https://doi.org/10.1038/s41467-021-26620-1.

#Protein Structure #X-ray Crystallography #Antibody #Angiogenesis #Cell Signaling #Drug Development #Collaboration

Ki H, Jo J, Kim Y, Kim TW, Kim C, Kim Y, Kim CW, Muniyappan S, Lee SJ, Kim Y, Kim HM, Yang Y, Rhee YM, Ihee H. Uncovering the Conformational Distribution of a Small Protein with Nanoparticle-Aided Cryo-Electron Microscopy Sampling. J Phys Chem Lett. 2021 Jul 22;12(28):6565-6573

#Cryo-EM #Biophysics #Collaboration

Jeong D, Kim HS, Kim HY, Kang MJ, Jung H, Oh Y, Kim D, Koh J, Cho S-Y, Jeon YK, Lee EB, Lee SH, Shin E-C, Kim HM, Yi EC, Chung DH. Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2. Elife. 2021 Jul 5;10: e48840. doi: 10.7554/eLife.48840

#Protein Structure #Computational Structure Biology #Ligand/Receptor Complex #Immune Response #Collaboration

Ahn JH, Kim J, Hong SP, Choi SY, Yang MJ, Ju YS, Kim YT, Kim HM, Rahman T, Chung MK, Hong SD, Bae H, Lee C-S, Koh GY. Nasal ciliated cells are primary targets for SARS-CoV-2 replication in early stage of COVID-19. J Clin Invest. 2021 Jul 1;131(13):e148517. doi: 10.1172/JCI148517

#Protein Science #Infectious Disease #Human Disease #Collaboration

Kim D-K, Bandara G, Cho Y-E, Komarow H, Donahue D, Karim B, Baek M-C, Kim HM, Metcalfe D, and Olivera A. Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation. Nature Communications. 2021 May 5;12(1):2527

#Protein Science #Human Disease #Collaboration

Jang S, Song J, Kim NY, Bak J, Jung K, Park YW, Park B-C*, Kim HM*. Development of an Antibody-Like T-cell Engager based on VH-VL heterodimer formation and its application in cancer therapy. Biomaterials. 2021 Apr;271:120760

#Protein Engineering #Drug Development #Human Disease #Cancer #Collaboration

2020

Han S, Kim Y-N, Jo G, Kim YE, Kim HM, Choi J-M, Jung Y. Multivalent-Interaction-Driven Assembly of Discrete, Flexible, and Asymmetric Supramolecular Protein Nano-Prisms. Angew Chem Int Ed Engl. 2020 Dec 14;59(51):23244-23251

#Protein Science #Protein Engineering #Negative Stain EM #Collaboration

Youk J, Kim T, Evans KV, Jeong Y-I, Hur Y, Hong SP, Kim JH, Yi K, Kin SY, Na KJ, Bleasard T, Kim HM, Fellow M, Mahbubani KT, Saeb-Parsy K, Kim SY, Kim YT, Koh GY, Choi B-S, Ju YS, Lee J-H. Three-dimensional human alveolar stem cell culture models reveal infection response to SARS-CoV-2. Cell Stem Cell. 2020 Dec 3;27(6):905-919

#Protein Science #Human Disease #Infectious Disease #Collaboration

Kim S, Yun J, Yoo H, Kim S, Kim HM*, Lee HS*. Metal-mediated protein oligomerization using a genetically incorporated metal-chelation amino acid. Biomacromolecules. 2020 Nov 30; 21(12), 5021-5028

#Protein Science #Protein Engineering #Negative Stain EM #Collaboration

Hong HK, Park YJ, Kim DK, Ryo N-K, Ko Y-J, Park KH, Kim HM*, Woo SJ*. Preclinical Efficacy and Safety of VEGF-Grab, A Novel anti-VEGF drug, and Its Comparison to Aflibercept. Investigative Ophthalmology & Visual Science. 2020 Nov 2;61(13):22

#Protein Science #Protein Engineering #Anti-angiogenesis #Drug Development #Human Disease #Collaboration

Park BS, Won SY, Lee DS, Kim HM*. Human leucine-rich-alpha-2-glycoprotein1: purification, crystallization, and X-ray crystallographic analysis. Biodesign. 2020; 8(3): 60-63

#Protein Structure #X-ray Crystallography

Kim G, Lee S-G, Han S, Jung J, Jeong HS, Hyun J-K, Rhee D-K, Kim HM*, Lee S*. ClpL is a functionally active tetradecameric AAA+ chaperone, distinct from hexameric/dodecameric ones. FASEB J. 2020 Nov;34(11):14353-14370

#Protein Structure #Cryo-EM #Infectious Disease #Collaboration

Khoo ATT, Kim PJ, Kim HM, Je HS. Neural Circuit Analysis Using a Novel Intersectional Split Intein-Mediated split-Cre Recombinase System. Mol Brain. 2020 Jul 2;13(1):101

#Protein Science #Protein Engineering #Neuroscience #Collaboration

Jeong E, Lee S-G, Kim H-S, Yang J, Shin J, Kim Y, Kim J, Schärer OD, Kim Y, Yeo J-E, Kim HM, Cho Y. Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex. Nucleic Acids Res. 2020 Apr 6;48(6):3328-3342

#Protein Structure #Cryo-EM #Cancer #Collaboration

Kim S, Kyung T, Chung JH, Kim N, Keum S, Lee J, Park H, Kim HM, Lee S, Shin HS, Do Heo W. Non-invasive optical control of endogenous Ca2+ channels in awake mice. Nat Commun. 2020 Jan 10;11(1):210

#Protein Science #Protein Engineering #Neuroscience #Collaboration

Chung JH, Hong SH, Seo N, Kim TS, An HJ, Lee P, Shin EC*, Kim HM*. Structure-based glycoengineering of interferon lambda 4 enhances its productivity and anti-viral potency. Cytokine. 2020 Jan;125:154833

#Protein Science #Protein Engineering #Immune Response #Infectious Disease #Collaboration

2018

Kwon MJ, Han MH, Bagley JA, Hyeon DY, Ko BS, Lee YM, Cha IJ, Kim SY, Kim DY, Kim HM, Hwang D, Lee SB, Jan YN. Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects. Proc Natl Acad Sci U S A. 2018 Oct 22. pii: 201807206.

#Protein Science #Protein Structure #Neuroscience #Collaboration

Kim HM*, Kim YM*. HMGB1: LPS Delivery Vehicle for Caspase-11-Mediated Pyroptosis (Preview). Immunity. 2018 Oct 16;49(4):582-584.

#Immune response #Review

Yoon HR, Choi H, Choi YA, Kim JA, Jung J, Kim HM, Jung Y. Fabrication of Oligomeric Avidin Scaffolds for Valency-Controlled Surface Display of Functional Ligands. Angew Chem Int Ed Engl. 2018 Sep 17;57(38):12410-12414.

#Protein Science #Protein Engineering #Negative stain EM #Collaboration

Yin GN, Jin H-R, Choi M-J, Limanjaya A, Ghatak K, Minh NN, Kwon M-H, Song K-M, Park HJ, Kim HM, Kwon Y-G, Ryu J-K and Suh J-K. Pericyte-Derived Dickkopf2 Regenerates Damaged Penile Neurovasculature Through an Angiopoietin-1-Tie2 Pathway. Diabetes. 2018 Jun;67(6):1149-1161.

#Protein Science #Angiogenesis #Human Disease #Collaboration

Won SY, Kim HM*. Structural Basis for LAR-RPTP-Mediated Synaptogenesis. Mol Cells. 2018 Jul 31;41(7):622-630.

#Protein Structure #Neuroscience #Review

Lee JH, Park BS, Han KR, Biering SB, Kim SJ, Choi J, Seok JH, Alam I, Chung MS, Kim HM, Hwang S, Kim KH. Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication. Front. Microbiol., 2018 Jul 03;9:1466.

#Protein Structure #Infectious Disease #Collaboration

Lee DH, Lee MY, Seo Y, Hong HJ, An HJ, Kang JS*, Kim HM*. Multi-paratopic VEGF decoy receptor have superior anti-tumor effects through anti-EGFRs and targeted anti-angiogenic activities. Biomaterials. 2018 Apr 16;171:34-45.

#Protein Engineering #Anti-angiogenesis #Cancer #Drug Development #Human Disease #Collaboration

Seo BA, Lee JH, Kim HM*, Kang MG*. Neuronal calcium channel α1 subunit interacts with AMPA receptor, increasing its cell surface localization. Biochem Biophys Res Commun. 2018 Apr 6;498 (3):402-408.

#Protein Science #Cell Siganling #Neuroscience #Collaboration

Ahn B, Lee S-G, Yoon HR, Lee JM, Oh HJ, Kim HM*, Jung Y*. Four-fold Channel-Nicked Human Ferritin Nanocages for Active Drug Loading and pH-Responsive Drug Release. Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2909-2913.

#Protein Science #Protein Engineering #Negative stain EM #Collaboration

2017

Kim SY, Jeong JM, Kim SJ, Seo W, Kim MH, Choi WM, Yoo W, Lee JH, Shim YR, Yi HS, Lee YS, Eun HS, Lee BS, Chun K, Kang SJ, Kim SC,7, Gao B, Kunos G, Kim HM, Jeong WI. Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4-MD2 complex. Nature Communications. 2017 Dec 21;8(1):2247.

#Protein Science #Cell Signaling #Collaboration

Ghatak K, Yin GN, Choi MJ, Limanjaya A, Minh NN, Ock J, Song KM, Kang DH, Kwon YG, Kim HM, Ryu JK, Suh JK. Dickkopf2 rescues erectile function by enhancing penile neurovascular regeneration in a mouse model of cavernous nerve injury. Sci Rep. 2017 Dec 19;7(1):17819.

#Protein Science #Angiogenesis #Human Disease #Collaboration

Won SY, Kim CY, Kim D, Ko J, Um JW, Lee SB, Buck M, Kim E, Heo WD*, Lee JO*, Kim HM*. LAR-RPTP Clustering Is Modulated by Competitive Binding between Synaptic Adhesion Partners and Heparan Sulfate. Frontiers in Molecular Neuroscience. 2017 Oct 13;10:327.

#Protein Structure #X-ray Crystallography #Cell Signaling #Neuroscience #Collaboration

Joo K, Park SJ, Choi Y, Lee JE, Na YM, Hong HK, Park KH, Kim HM*, Chung JY*, and Woo SJ*. Role of the Fc Region in the Vitreous Half-life of Anti-VEGF Drugs. Investigative Ophthalmology & Visual Science. 2017 Aug 1;58(10):4261-4267.

#Protein Science #Protein Engineering #Human Disease #Collaboration

Kim JA, Kim D, Won SY, Han KA, Park D, Cho E, Yun N, An HJ, Um JW, Kim E, Lee JO, Ko J*, Kim HM*. Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1/Neuroligin-2 Complex. Neuron. 2017 Jun 21;94(6):1121-1131.e6. doi: 10.1016/j.neuron.2017.05.034. Selected as Issue Highlights.

#Protein Structure #X-ray Crystallography #Neuroscience #Collaboration

Sung PS, Hong SH, Chung JH, Kim S, Park SH, Kim HM, Yoon SK, Shin EC. IFN-λ4 potently blocks IFN-α signalling by ISG15 and USP18 in hepatitis C virus infection. Sci Rep. 2017 Jun 19;7(1):3821.

#Protein Science #Infectious Disease #Human Disease #Collaboration

Kim SJ, Kim HM*. Dynamic lipopolysaccharide transfer cascade to TLR4/MD2 complex via LBP and CD14. BMB Rep. 2017 Feb;50(2):55-57.

#Protein Structure #Immune Response #Review

Ryu J-K, Kim SJ, Rah S-H, Kang JI, Jung HE, Lee D, Lee HK, Lee J-O, Park BS, Yoon T-Y*, Kim HM*. Reconstruction of LPS transfer cascade reveals structural determinants within LBP, CD14 and TLR4-MD2 for efficient LPS recognition and transfer. Immunity. 2017 Jan 17;46(1):38-50. doi: 10.1016/j.immuni.2016.11.007. *Recommended by Faculty of 1000 Biology

#Protein Structure #Biophysics #Negative Stain EM #Immune Response #Collaboration

2016

Lee H, Hong D, Cho H, Kim JY, Park JH, Lee SH, Kim HM, Fakhrullin RF, Choi IS. Turning Diamagnetic Microbes into Multinary Micro-Magnets: Magnetophoresis and Spatio-Temporal Manipulation of Individual Living Cells. Sci. Rep. 2016 Dec 5;6:38517. doi: 10.1038/srep38517.

#EM #Collaboration

Das ND, Yin GN, Choi MJ, Song KM, Park JM, Limanjaya A, Ghatak K, Minh NN, Ock J, Park SH, Kim HM, Ryu JK, Suh JK. Effectiveness of Intracavernous Delivery of Recombinant Human Hepatocyte Growth Factor on Erectile Function in the Streptozotocin-Induced Diabetic Mouse. J Sex Med. 2016 Nov;13(11):1618-1628. doi: 10.1016/j.jsxm.2016.09.017.

#Protein Science #Angiogenesis #Human Disease #Collaboration

Kang H, Han KA, Won SY, Kim HM, Lee Y-H, Ko J, Um JW. Slitrk Missense Mutations Associated with Neuropsychiatric Disorders Distinctively Impair Slitrk Trafficking and Synapse Formation. Front. Mol. Neurosci. 2016 Oct 20;9:104.

#Protein Structure #Human Disease #Neuroscience #Collaboration

Lie E, Ko JS, Choi SY, Roh J, Cho YS, Noh R, Kim D, Li Y, Kang H, Choi TY, Nam J, Mah W, Lee D, Lee SG, Kim HM, Kim H, Choi SY, Um JW, Kang MG, Bae YC, Ko J and Kim E. SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion. Nature Communications. 2016 Aug 2;7:12328.

#Protein Science #Neuroscience #Collaboration

Choi Y, Nam J, Whitcomb DJ, Song YS, Kim D, Jeon S, Um JW, Lee SG, Woo J, Kwon SK, Li Y, Mah W, Kim HM, Ko J, Cho K, Kim E. SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development. Sci Rep. 2016 May 26;6:26676.

#Protein Science #Neuroscience #Collaboration

Han KA, Woo D, Kim S, Choii G, Jeon S, Won SY, Kim HM, Heo WD, Um JW, Ko J. Neurotrophin-3 regulates synapse development by modulating TrkC-PTPσ synaptic adhesion and intracellular signaling pathways. J. Neurosci. 2016 Apr 27;36(17):4816-31.

#Protein Science #Neuroscience #Collaboration

Lee JM, Kim JA, Yen TC, Lee IH, Ahn B, Lee Y, Hsieh CL, Kim HM, Jung Y. A Rhizavidin Monomer with Nearly Multimeric Avidin-Like Binding Stability Against Biotin Conjugates. Angew Chem Int Ed Engl. 2016 Mar 1;55(10):3393-7.

#Protein Science #Protein Engineering #Negative stain EM #Collaboration

2015

Oh N, Kim K, Kim SJ, Park I, Lee JE, Seo YS, An HJ, Kim HM*, Koh GY*. A Designed Angiopoietin-1 Variant, Dimeric CMP-Ang1 Activates Tie2 and Stimulates Angiogenesis and Vascular Stabilization in N-glycan Dependent Manner. Scientific Reports. 2015 Oct 19; 5:15291.

#Protein Science #Protein Engineering #Negative stain EM #Collaboration

Lee J, Chung J-H, Kim HM, Kim D-W, Kim H. Designed Nucleases for targeted genome editing. Plant Biotechnol J., 2015 Sep 15; DOI: 10.1111/pbi.12465.

#Protein Structure #Review #Collaboration

Yang KS, Sung BH, Park MK, Lee JH, Lim KJ, Park SC, Kim SJ, Kim HK, Sohn J-H, Kim HM*, Kim SC*. A recombinant lipase engineered with amphipathic and coiled-coil peptides. ACS Catal. 2015 July 17; DOI: 10.1021/cs502079g.

#Protein Science #Protein Engineering #Collaboration

Kim YN, Kim JA, Kim HM, Jung Y. Green fluorescent protein nanopolygons as monodisperse supramolecular assemblies of functional proteins with defined valency. Nature Communications. 2015 May 14; DOI: 10.1038/ncomms8134

#Protein Science #Protein Engineering #Negative stain EM #Collaboration

Kim YR, Kim S, Choi JW, Choi SY, Lee SH, Kim HM, Hahn SK, Koh GY, Yun SH. Bioluminescence-activated deep-tissue photodynamic therapy of cancer. Theranostics. 2015; 5(8):805-817.

#Negative stain EM #Drug Development #Cancer #Collaboration

SJ Park, J Oh, Y-K Kim, JH Park, JY Park, HK Hong, KH Park, J-E Lee, HM Kim, JY Chung, SJ Woo. Intraocular pharmacokinetics of intravitreal vascular endothelial growth factor-Trap in a rabbit model. Eye (Lond). 2015 Apr;29(4):561-8.

#Protein Science #Protein Engineering #Drug Development #Collaboration

Lim JS, Kim WI, Kang HC, Kim SH, Park AH, Park EK, Cho YW, Kim S, Kim HM, Kim JA, Kim J, Rhee H, Kang SG, Kim HD, Kim D, Kim DS, Lee JH. Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy. Nature Medicine. 2015 Apr; 21(4): 395-400

#Protein Structure #Human Disease #Collaboration

Ryu JK, Min D, Rah SH, Kim SJ, Park Y, KimH, Hyeon C, Kim HM, Jahn R, Yoon TY. Spring-Loaded Unraveling of a Single SNARE Complex by NSF in One Round of ATP Turnover. Science. 2015 Mar 27; 347(6229): 1485-1489.

#Protein Science #Protein Structure #Biophysics #Collaboration

Lee J, Kim C, Yang H, Park I, Oh N, Hua S, Jeong H, An H, Kim SC, Lee GM, Koh GY*, Kim HM*. Novel Glycosylated VEGF Decoy Receptor Fusion Protein, VEGF-Grab, Efficiently Suppresses Tumor Angiogenesis and Progression. Mol Cancer Ther. 2015 Feb;14(2):470-9. Selected as Issue Highlights.

#Protein Science #Protein Engineering #Drug Development #Collaboration

Ko JS, Pramanik G, Um JW, Shim JS, Lee D, Kim KH, Chung GY, Condomitti G, Kim HM, Kim H, de Wit J, Park KS, Tabuchi K, Ko J. PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1874-9.

#Protein Science #Neuroscience #Collaboration

Do H, Kim SJ, Lee CW, Kim H, Park HH, Kim HM, Park H, Park H and Lee JH, Crystal structure of UbiX, an aromatic acid decarboxylase from the psychrophilic bacterium Colwellia psychrerythraea that undergoes FMN-induced conformational changes. Scientific Reports. 2015 Feb 03;5:8196.

#Protein Structure #Negative stain EM #Collaboration

Soh YM, Burmann F, Shin HC, Oda T, Jin KS, Toseland CP, Kim C, Lee H, Kim SJ, Kong MS, Durand-Diebold ML, Kim YG, Kim HM, Lee NK, Sato M, Oh BH, Gruber S. Molecular Basis for SMC Rod Formation and Its Dissolution upon DNA Binding. Mol Cell. 2015 Jan 22;57(2):290-303.

#Protein Structure #Negative stain EM #Collaboration

Lee H, Hong D, Choi JY, Kim JY, Lee SH, Kim HM, Yang SH, Choi IS. Layer-by-Layer-Based Silica Encapsulation of Individual Yeast with Thickness Control. Chem Asian J. 2015 Jan;10(1):129-32.

#EM #Collaboration

~2010

Koh YJ, Kim HZ, Hwang SI, Lee JE, Oh N, Jung K, Kim M, Kim KE, Kim HM, Lim NK, Jeon CJ, Lee GM, Jeon BH, Nam DH, Sung HK, Nagy A, Yoo OJ, Koh GY. Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage. Cancer cell, 2010 Aug 17 ;18(2): 171–184.

#Protein Science #Protein Engineering #Collaboration

Yu Y, Smith DM, Kim HM, Rodriguez V, Goldberg AL, Cheng Y. Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions. EMBO J. 2010 Feb 3;29(3):692-702.

#Protein Structure #Collaboration

Min SH, Kim DM, Heo YS, Kim HM, Kim IC, Yoo OJ. Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2. Life Sci. 2010 Jan 2;86(1-2):66-72.

#Protein Science #Collaboration

Jung K, Lee JE, Kim HZ, Kim HM, Park BS, Hwang SI, Lee JO, Kim SC, Koh GY. Toll-like receptor 4 decoy, TOY, attenuates gram-negative bacterial sepsis. PLoS One. 2009 Oct 9;4(10).

#Protein Science #Protein Engineering #Collaboration

Kim HZ, Jung K, Kim HM, Cheng Y, Koh GY. A Designed Angiopoietin-2 Variant, Pentameric COMP-Ang2, Strongly Activates Tie2 Receptor and Stimulates Angiogenesis. Biochim Biophys Acta. 2009 May; 1793(5):772-80.

#Protein Science #Protein Engineering #Collaboration

Park BS, Song DH, Kim HM, Choi BS, Lee H, Lee JO. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature. 2009 Apr 30; 458(7242):1191-5 *Spotlight ACS Chem. Biol., 2009, 4 (4), pp 238–240, *recommended by Faculty of 1000 Biology.

#Protein Structure #X-ray Crystallography #Immune Response #Collaboration

Min SH, Kim DM, Heo YS, Kim YI, Kim HM, Kim J, Han YM, Kim IC, Yoo OJ. New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53. Oncogene. 2009 Jan 29;28(4):545-54.

#Protein Science #Collaboration

Lee KE, Kim HM, Lee JO, Jeon H, Han SS. Regulation of CD40 reconstitution into a liposome using different ratios of solubilized LDAO to lipids. Colloids Surf B Biointerfaces. 2008 Mar 15;62(1):51-7.

#Protein Science #EM #Biophysics #Collaboration

Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OK, Lee JO. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell, 2007 Sep 7; 130(5):906-17 *Spotlight ACS Chem. Biol., 2007, 2 (10), pp 642–645, *recommended by Faculty of 1000 Biology.

#Protein Structure #X-ray Crystallography #Immune Response

Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell. 2007 Sep 21; 130(6):1071-82 *recommended by Faculty of 1000 Biology.

#Protein Structure #X-ray Crystallography #Immune Response #Collaboration

Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO. Structural diversity of the hagfish variable lymphocyte receptors. J. Biol. Chem. 282(9): 6726-32 (2007).

#Protein Structure #X-ray Crystallography #Immune Response #Antibody

Yoon MK, Kim HM, Choi G, Lee JO, Choi BS. Structural basis for the conformational integrity of the Arabidopsis thaliana HY5 leucine zipper homodimer. J. Biol. Chem. 282(17): 12989-3002 (2007).

#Protein Structure #X-ray Crystallography #Collaboration

Kim HM, Yu KS, Lee ME, Shin DR, Kim YS, Paik SG, Yoo OJ, Lee H, Lee JO. Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation. Nat. Struct. Biol. 10(5): 342-8 (2003) * recommended by Faculty of 1000 Biology.

#Protein Structure #X-ray Crystallography #Immune Response

Kim HM, Shin DR, Yoo OJ, Lee H, Lee JO. Crystal structure of Drosophila angiotensin I-converting enzyme bound to captopril and lisinopril. FEBS Lett. 538(1-3): 65-70 (2003).

#Protein Structure #X-ray Crystallography

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